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Cellosaurus PC-346C (CVCL_4883)

[Text version]
Cell line name PC-346C
Synonyms PC346C
Accession CVCL_4883
Resource Identification Initiative To cite this cell line use: PC-346C (RRID:CVCL_4883)
Comments Characteristics: Established from the PC-346 xenograft (CelloPub=CLPUB00699).
Characteristics: Optimal proliferation of the cell line requires androgens and is inhibited by the antiandrogen hydroxyflutamide.
Doubling time: 4-5 days (CelloPub=CLPUB00699).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4882 (PC-346)
Children:
CVCL_B7J2 (PC-346CF)CVCL_RA53 (PC346Abi101)CVCL_IP21 (PC346DCC)
CVCL_RA54 (PC346Enza)CVCL_IP22 (PC346Flu1)CVCL_IP23 (PC346Flu2)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=11304728; PubMed=14518029

Markers:
AmelogeninX (PubMed=14518029_clone_2)
X,Y (PubMed=11304728; PubMed=14518029_clone_1)
D3S135816,18 (PubMed=11304728; PubMed=14518029_clone_1)
16,19 (PubMed=14518029_clone_2)
D5S81812,14
D7S8207,12
D8S117913,14
D13S31714
D18S5112,13
D21S1129,34.2
FGA19,24
vWA18,19 (PubMed=11304728; PubMed=14518029_clone_1)
19 (PubMed=14518029_clone_2)

Run an STR similarity search on this cell line
Publications

CLPUB00699
Johannes C. Romijn, Sigrun Erkens-Schulze, Wytske M. van Weerden, Wilma J. Teubel, Jan Trapman, Fritz H. Schroder;
Development and characterization of a new in vitro model to study the mechanisms of prostate cancer progression.
Urol. Res. 23:265.P81-265.P81(1995)

PubMed=11304728; DOI=10.1002/pros.1045
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Daphne Hessels, Gary J. Miller;
Widely used prostate carcinoma cell lines share common origins.
Prostate 47:36-51(2001)

PubMed=14518029; DOI=10.1002/pros.10290
Adrie van Bokhoven, Marileila Varella-Garcia, Christopher T. Korch, Widya U. Johannes, E. Erin Smith, Heidi L. Miller, Steven K. Nordeen, Gary J. Miller, M. Scott Lucia;
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=14518030; DOI=10.1002/pros.10291
Adrie van Bokhoven, Aimee Caires, Michael Di Maria, Aline Passarini Schulte, M. Scott Lucia, Steven K. Nordeen, Gary J. Miller, Marileila Varella-Garcia;
Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines.
Prostate 57:226-244(2003)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=15900601; DOI=10.1002/ijc.21201
Rute B. Marques, Sigrun Erkens-Schulze, Corrina M.A. de Ridder, Karin G. Hermans, Kati Waltering, Tapio Visakorpi, Jan Trapman, Johannes C. Romijn, Wytske M. van Weerden, Guido Jenster;
Androgen receptor modifications in prostate cancer cells upon long-term androgen ablation and antiandrogen treatment.
Int. J. Cancer 117:221-229(2005)

PubMed=20976069; DOI=10.1371/journal.pone.0013500; PMCID=PMC2957443
Rute B. Marques, Natasja F. Dits, Sigrun Erkens-Schulze, Wytske M. van Weerden, Guido Jenster;
Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models.
PLoS ONE 5:e13500.1-e13500.16(2010)

Cross-references
Anatomy/cell type resources BTO; BTO_0002831
Encyclopedic resources Wikidata; Q54938432
Gene expression databases GEO; GSM539100
GEO; GSM539101
GEO; GSM539102
GEO; GSM539103
GEO; GSM539104
GEO; GSM539105
GEO; GSM539106
GEO; GSM539107
GEO; GSM539108
GEO; GSM539109
GEO; GSM539110
GEO; GSM539111
GEO; GSM1374819
Polymorphism and mutation databases IARC_TP53; 21087
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number18