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Cellosaurus KBM-3/AMSA (CVCL_IP19)

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Cell line name KBM-3/AMSA
Accession CVCL_IP19
Resource Identification Initiative To cite this cell line use: KBM-3/AMSA (RRID:CVCL_IP19)
Comments Selected for resistance to: ChEBI; CHEBI_2687; Amsacrine.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; HGNC:11989; TOP2A; Simple; p.Arg487Lys (c.1460G>A); ClinVar=VCV000016772; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=1311390).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
Disease Adult acute myelomonocytic leukemia (NCIt: C7962)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A425 (KBM-3)
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line
Publications

PubMed=1311390; DOI=10.1016/0022-2836(92)90245-F
Ming-Sheng Lee, James Chuo Wang, Miloslav Beran;
Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II.
J. Mol. Biol. 223:837-843(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IP19
Encyclopedic resources Wikidata; Q54899583
Entry history
Entry creation03-Mar-2017
Last entry update14-Aug-2025
Version number15