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Cellosaurus BT159 (CVCL_IP11)

[Text version]
Cell line name BT159
Synonyms BT-159; BT 159; CPDM_1282X
Accession CVCL_IP11
Resource Identification Initiative To cite this cell line use: BT159 (RRID:CVCL_IP11)
Comments Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel.
Population: Caucasian.
Characteristics: Low-passage-number culture.
Characteristics: Can grow as a neurosphere (PubMed=34610309).
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, left temporal cortex; UBERON=UBERON_0016538.
Sequence variations
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 61Y
Category Cancer cell line
Web pages Provider; CPDM; CPDM_1282X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing
Publications

PubMed=25184684; DOI=10.1371/journal.pone.0106694; PMCID=PMC4153667
Holmberg Olausson K., Maire C.L., Haidar S., Ling J., Learner E., Nister M., Ligon K.L.
Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas.
PLoS ONE 9:e106694.1-e106694.11(2014)

PubMed=25366336; DOI=10.1093/neuonc/nou303; PMCID=PMC4482855
Green A.L., Ramkissoon S.H., McCauley D., Jones K., Perry J.A., Hsu J.H.-R., Ramkissoon L.A., Maire C.L., Hubbell-Engler B., Knoff D.S., Shacham S., Ligon K.L., Kung A.L.-J.
Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma.
Neuro-oncol. 17:697-707(2015)

PubMed=27723727; DOI=10.1038/nbt.3697; PMCID=PMC5142231
Stevens M.M., Maire C.L., Chou N., Murakami M.A., Knoff D.S., Kikuchi Y., Kimmerling R.J., Liu H.-Y., Haidar S., Calistri N.L., Cermak N., Olcum S., Cordero N.A., Idbaih A., Wen P.Y.-C., Weinstock D.M., Ligon K.L., Manalis S.R.
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nat. Biotechnol. 34:1161-1167(2016)

PubMed=34610309; DOI=10.1016/j.celrep.2021.109788
Stockslager M.A., Malinowski S., Touat M., Yoon J.C., Geduldig J., Mirza M., Kim A.S., Wen P.Y.-C., Chow K.-H., Ligon K.L., Manalis S.R.
Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models.
Cell Rep. 37:109788.1-109788.12(2021)

Cross-references
Anatomy/cell type resources BTO; BTO_0005951
Chemistry resources PharmacoDB; BT159_118_2019
Encyclopedic resources Wikidata; Q54798422
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number10