ID   BT159
AC   CVCL_IP11
SY   BT-159; BT 159; CPDM_1282X
DR   BTO; BTO_0005951
DR   PharmacoDB; BT159_118_2019
DR   Wikidata; Q54798422
RX   PubMed=25184684;
RX   PubMed=25366336;
RX   PubMed=27723727;
RX   PubMed=34610309;
WW   Provider; CPDM; CPDM_1282X; https://docs.google.com/spreadsheets/d/1sxAPF3p6xK2h01zaiQ1ExCWwzhxeZ-oDLN3s3LeJq98/edit?usp=sharing
CC   Part of: Center for Patient Derived Models (CPDM) at Dana-Farber Cancer Institute cell line panel.
CC   Population: Caucasian.
CC   Characteristics: Low-passage-number culture.
CC   Characteristics: Can grow as a neurosphere (PubMed=34610309).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=27723727).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing; Low read coverage.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Brain, left temporal cortex; UBERON=UBERON_0016538.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 10-04-25; Version: 10
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RX   PubMed=25184684; DOI=10.1371/journal.pone.0106694; PMCID=PMC4153667;
RA   Holmberg Olausson K., Maire C.L., Haidar S., Ling J., Learner E.,
RA   Nister M., Ligon K.L.;
RT   "Prominin-1 (CD133) defines both stem and non-stem cell populations in
RT   CNS development and gliomas.";
RL   PLoS ONE 9:e106694.1-e106694.11(2014).
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RX   PubMed=25366336; DOI=10.1093/neuonc/nou303; PMCID=PMC4482855;
RA   Green A.L., Ramkissoon S.H., McCauley D., Jones K., Perry J.A.,
RA   Hsu J.H.-R., Ramkissoon L.A., Maire C.L., Hubbell-Engler B., Knoff D.S.,
RA   Shacham S., Ligon K.L., Kung A.L.-J.;
RT   "Preclinical antitumor efficacy of selective exportin 1 inhibitors in
RT   glioblastoma.";
RL   Neuro-oncol. 17:697-707(2015).
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RX   PubMed=27723727; DOI=10.1038/nbt.3697; PMCID=PMC5142231;
RA   Stevens M.M., Maire C.L., Chou N., Murakami M.A., Knoff D.S.,
RA   Kikuchi Y., Kimmerling R.J., Liu H.-Y., Haidar S., Calistri N.L.,
RA   Cermak N., Olcum S., Cordero N.A., Idbaih A., Wen P.Y.-C.,
RA   Weinstock D.M., Ligon K.L., Manalis S.R.;
RT   "Drug sensitivity of single cancer cells is predicted by changes in
RT   mass accumulation rate.";
RL   Nat. Biotechnol. 34:1161-1167(2016).
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RX   PubMed=34610309; DOI=10.1016/j.celrep.2021.109788;
RA   Stockslager M.A., Malinowski S., Touat M., Yoon J.C., Geduldig J.,
RA   Mirza M., Kim A.S., Wen P.Y.-C., Chow K.-H., Ligon K.L., Manalis S.R.;
RT   "Functional drug susceptibility testing using single-cell mass
RT   predicts treatment outcome in patient-derived cancer neurosphere
RT   models.";
RL   Cell Rep. 37:109788.1-109788.12(2021).
//