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Cellosaurus KB-CP20 (CVCL_IP06)

[Text version]
Cell line name KB-CP20
Accession CVCL_IP06
Resource Identification Initiative To cite this cell line use: KB-CP20 (RRID:CVCL_IP06)
Comments Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IP05 (KB-CP10)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line

PubMed=7710928; DOI=10.1038/bjc.1995.380
Shen D.-W., Akiyama S.-i., Schoenlein P., Pastan I., Gottesman M.M.
Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.
Br. J. Cancer 71:676-683(1995)

Shen D.-W., Pastan I., Gottesman M.M.
Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.
Cancer Res. 58:268-275(1998)

PubMed=22571463; DOI=10.1021/mp300153z
Shen D.-W., Pouliot L.M., Gillet J.-P., Ma W.-T., Johnson A.C., Hall M.D., Gottesman M.M.
The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin.
Mol. Pharm. 9:1822-1833(2012)

Anatomy/cell type resources BTO; BTO:0006409
Encyclopedic resources Wikidata; Q54899557
Gene expression databases GEO; GSM743499
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number10