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Cellosaurus KB-CP20 (CVCL_IP06)

[Text version]
Cell line name KB-CP20
Accession CVCL_IP06
Resource Identification Initiative To cite this cell line use: KB-CP20 (RRID:CVCL_IP06)
Comments Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_IP05 (KB-CP10)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=7710928; DOI=10.1038/bjc.1995.134; PMCID=PMC2033730
Ding-Wu Shen, Shin-ichi Akiyama, Patricia V. Schoenlein, Ira Pastan, Michael Marc Gottesman;
Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes.
Br. J. Cancer 71:676-683(1995)

PubMed=9443404
Ding-Wu Shen, Ira Pastan, Michael Marc Gottesman;
Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins.
Cancer Res. 58:268-275(1998)

PubMed=22571463; DOI=10.1021/mp300153z; PMCID=PMC3367311
Ding-Wu Shen, Lynn M. Pouliot, Jean-Pierre Gillet, Wen-Ting Ma, Alfred C. Johnson, Matthew D. Hall, Michael Marc Gottesman;
The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin.
Mol. Pharm. 9:1822-1833(2012)

Cross-references
Anatomy/cell type resources BTO; BTO_0006409
Encyclopedic resources Wikidata; Q54899557
Gene expression databases GEO; GSM743499
Entry history
Entry creation03-Mar-2017
Last entry update10-Apr-2025
Version number12