ID   KB-CP20
DR   BTO; BTO:0006409
DR   GEO; GSM743499
DR   Wikidata; Q54899557
RX   PubMed=7710928;
RX   PubMed=9443404;
RX   PubMed=22571463;
CC   Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_IP05 ! KB-CP10
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 03-03-17; Last updated: 05-10-23; Version: 10
RX   PubMed=7710928; DOI=10.1038/bjc.1995.380;
RA   Shen D.-W., Akiyama S.-i., Schoenlein P.V., Pastan I., Gottesman M.M.;
RT   "Characterisation of high-level cisplatin-resistant cell lines
RT   established from a human hepatoma cell line and human KB
RT   adenocarcinoma cells: cross-resistance and protein changes.";
RL   Br. J. Cancer 71:676-683(1995).
RX   PubMed=9443404;
RA   Shen D.-W., Pastan I., Gottesman M.M.;
RT   "Cross-resistance to methotrexate and metals in human
RT   cisplatin-resistant cell lines results from a pleiotropic defect in
RT   accumulation of these compounds associated with reduced plasma
RT   membrane binding proteins.";
RL   Cancer Res. 58:268-275(1998).
RX   PubMed=22571463; DOI=10.1021/mp300153z;
RA   Shen D.-W., Pouliot L.M., Gillet J.-P., Ma W.-T., Johnson A.C.,
RA   Hall M.D., Gottesman M.M.;
RT   "The transcription factor GCF2 is an upstream repressor of the small
RT   GTPAse RhoA, regulating membrane protein trafficking, sensitivity to
RT   doxorubicin, and resistance to cisplatin.";
RL   Mol. Pharm. 9:1822-1833(2012).