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Cellosaurus KB-CP.5 (CVCL_IP04)

[Text version]
Cell line name KB-CP.5
Synonyms KCP.5
Accession CVCL_IP04
Resource Identification Initiative To cite this cell line use: KB-CP.5 (RRID:CVCL_IP04)
Comments Problematic cell line: Contaminated. Grand-parent cell line (KB) has been shown to be a HeLa derivative.
Population: African American.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2088 (KB-3-1)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=22571463; DOI=10.1021/mp300153z
Shen D.-W., Pouliot L.M., Gillet J.-P., Ma W.-T., Johnson A.C., Hall M.D., Gottesman M.M.
The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin.
Mol. Pharm. 9:1822-1833(2012)

Cross-references
Anatomy/cell type resources BTO; BTO:0005849
Encyclopedic resources Wikidata; Q54899555
Gene expression databases GEO; GSM743497
Entry history
Entry creation03-Mar-2017
Last entry update05-Oct-2023
Version number9