Cellosaurus cell line CFI-3 (CVCL

Cellosaurus CFI-3 (CVCL_IN79)

Cross-references
Cell line name	CFI-3
Accession	CVCL_IN79
Resource Identification Initiative	To cite this cell line use: CFI-3 (RRID:CVCL_IN79)
Comments	Population: North African. Doubling time: 24 hours (PubMed=1718974). Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen (Note=pMK16). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Fetal intestine; UBERON=UBERON_0000160.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Ser549Asn (c.1646G>A); ClinVar=VCV000007116; Zygosity=Heterozygous (PubMed=1718974). Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Asn1303Lys (c.3909C>G); ClinVar=VCV000007136; Zygosity=Heterozygous (PubMed=1718974).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_9640 ! CFT-1
Sex of cell	Sex unspecified
Age at sampling	18FW
Category	Transformed cell line
Publications	PubMed=1718974; DOI=10.1016/S0021-9258(18)54846-8 Eric Chastre, Yolande Di Gioia, Pascal Barbry, Brigitte Simon-Bouy, Etienne Mornet, Pascale Fanen, Guy Champigny, Shahin Emami, Christian Gespach; Functional insertion of the SV40 large T oncogene in cystic fibrosis intestinal epithelium. Characterization of CFI-3 cells. J. Biol. Chem. 266:21239-21246(1991) PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040 Dieter C. Gruenert, Marjolaine Willems, Jean-Jacques Cassiman, Raymond A. Frizzell; Established cell lines used in cystic fibrosis research. J. Cyst. Fibros. 3:191-196(2004)
Encyclopedic resources	Wikidata; Q54811444
Entry history
Entry creation	01-Dec-2016
Last entry update	27-Nov-2025
Version number	14