Cellosaurus cell line JME/CF 15 (CVCL

Cellosaurus JME/CF 15 (CVCL_IN70)

Cross-references
Cell line name	JME/CF 15
Synonyms	JME/CF15
Accession	CVCL_IN70
Resource Identification Initiative	To cite this cell line use: JME/CF 15 (RRID:CVCL_IN70)
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Nose, nasal cavity, epithelium; UBERON=UBERON_0005384.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=1701980).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=1701980; DOI=10.1152/ajplung.1990.259.6.L496 Douglas M. Jefferson, John D. Valentich, Frank C. Marini, Shelley A. Grubman, Michael C. Iannuzzi, Henry L. Dorkin, Ming Li, Katherine W. Klinger, Michael James Welsh; Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines. Am. J. Physiol. 259:L496-L505(1990) PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040 Dieter C. Gruenert, Marjolaine Willems, Jean-Jacques Cassiman, Raymond A. Frizzell; Established cell lines used in cystic fibrosis research. J. Cyst. Fibros. 3:191-196(2004) PubMed=19584307; DOI=10.1124/jpet.109.155341 Sara Rafferty, Nicole Alcolado, Caroline Norez, Frederic Chappe, Siegried Pelzer, Frederic Becq, Valerie Chappe; Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15. J. Pharmacol. Exp. Ther. 331:2-13(2009)
Encyclopedic resources	Wikidata; Q54899007
Entry history
Entry creation	01-Dec-2016
Last entry update	14-Aug-2025
Version number	17