ID   JME/CF 15
AC   CVCL_IN70
SY   JME/CF15
DR   Wikidata; Q54899007
RX   PubMed=1701980;
RX   PubMed=15463957;
RX   PubMed=19584307;
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=1701980).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Nose, nasal cavity, epithelium; UBERON=UBERON_0005384.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 01-12-16; Last updated: 19-12-24; Version: 16
//
RX   PubMed=1701980; DOI=10.1152/ajplung.1990.259.6.L496;
RA   Jefferson D.M., Valentich J.D., Marini F.C., Grubman S.A.,
RA   Iannuzzi M.C., Dorkin H.L., Li M., Klinger K.W., Welsh M.J.;
RT   "Expression of normal and cystic fibrosis phenotypes by continuous
RT   airway epithelial cell lines.";
RL   Am. J. Physiol. 259:L496-L505(1990).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   PubMed=19584307; DOI=10.1124/jpet.109.155341;
RA   Rafferty S., Alcolado N., Norez C., Chappe F., Pelzer S., Becq F.,
RA   Chappe V.;
RT   "Rescue of functional F508del cystic fibrosis transmembrane
RT   conductance regulator by vasoactive intestinal peptide in the human
RT   nasal epithelial cell line JME/CF15.";
RL   J. Pharmacol. Exp. Ther. 331:2-13(2009).
//