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Cellosaurus SKVCR2.0 (CVCL_IN09)

[Text version]
Cell line name SKVCR2.0
Synonyms SKVCR 2.0; SK VCR 2
Accession CVCL_IN09
Resource Identification Initiative To cite this cell line use: SKVCR2.0 (RRID:CVCL_IN09)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line

Bradley G., Naik M., Ling V.
P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.
Cancer Res. 49:2790-2796(1989)

PubMed=17726699; DOI=10.1002/gcc.20492
Buys T.P.H., Chari R., Lee E.H.L., Zhang M., MacAulay C., Lam S., Lam W.L., Ling V.
Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.
Genes Chromosomes Cancer 46:1069-1079(2007)

Cell line databases/resources cancercelllines; CVCL_IN09
Encyclopedic resources Wikidata; Q54954807
Gene expression databases GEO; GSM183342
GEO; GSM183344
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number14