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Cellosaurus SKVCR2.0 (CVCL_IN09)

[Text version]
Cell line name SKVCR2.0
Synonyms SKVCR 2.0; SK VCR 2
Accession CVCL_IN09
Resource Identification Initiative To cite this cell line use: SKVCR2.0 (RRID:CVCL_IN09)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

PubMed=2565764
Bradley G., Naik M., Ling V.
P-glycoprotein expression in multidrug-resistant human ovarian carcinoma cell lines.
Cancer Res. 49:2790-2796(1989)

PubMed=17726699; DOI=10.1002/gcc.20492
Buys T.P.H., Chari R., Lee E.H.-L., Zhang M., MacAulay C., Lam S., Lam W.L., Ling V.
Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells.
Genes Chromosomes Cancer 46:1069-1079(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IN09
Encyclopedic resources Wikidata; Q54954807
Gene expression databases GEO; GSM183342
GEO; GSM183344
Entry history
Entry creation01-Dec-2016
Last entry update10-Apr-2025
Version number16