ID   SKVCR2.0
AC   CVCL_IN09
SY   SKVCR 2.0; SK VCR 2
DR   cancercelllines; CVCL_IN09
DR   GEO; GSM183342
DR   GEO; GSM183344
DR   Wikidata; Q54954807
RX   PubMed=2565764;
RX   PubMed=17726699;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C7978; Ovarian serous cystadenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0532 ! SK-OV-3
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 10-04-25; Version: 16
//
RX   PubMed=17726699; DOI=10.1002/gcc.20492;
RA   Buys, Timon P.H.
RA   Chari, Raj
RA   Lee, Eric H.-L.
RA   Zhang, May
RA   MacAulay, Calum
RA   Lam, Stephen
RA   Lam, Wan L.
RA   Ling, Victor
RT   "Genetic changes in the evolution of multidrug resistance for cultured
RT   human ovarian cancer cells.";
RL   Genes Chromosomes Cancer 46:1069-1079(2007).
//
RX   PubMed=2565764;
RA   Bradley, Grace
RA   Naik, Michael
RA   Ling, Victor
RT   "P-glycoprotein expression in multidrug-resistant human ovarian
RT   carcinoma cell lines.";
RL   Cancer Res. 49:2790-2796(1989).
//