| Cell line name |
Ishikawa-RP |
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| Synonyms |
Ishikawa-Resistant to Progestin |
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| Accession |
CVCL_IJ14 |
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| Resource Identification Initiative |
To cite this cell line use: Ishikawa-RP (RRID:CVCL_IJ14) |
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| Comments |
Population: Japanese.
Doubling time: 34.18 +- 3.15 hours (PubMed=23255909).
Selected for resistance to: ChEBI; CHEBI_6716; Medroxyprogesterone acetate (MPA).
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295. |
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| Sequence variations |
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Type I endometrial adenocarcinoma (NCIt: C40145) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2529 (Ishikawa) |
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| Sex of cell |
Female |
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| Age at sampling |
39Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=23255909; DOI=10.3892/ol.2012.975; PMCID=PMC3525505
Shun-Jun Zhao, Gen-Xia Li, Li Yang, Lei Li, Hong-Yu Li;
Response-specific progestin resistance in a newly characterized Ishikawa human endometrial cancer subcell line resulting from long-term exposure to medroxyprogesterone acetate.
Oncol. Lett. 5:139-144(2013) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_IJ14
|
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| Encyclopedic resources |
Wikidata; Q54898304
|
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 11 |
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