Cellosaurus cell line BIONi010-C-6 (CVCL

Cellosaurus BIONi010-C-6 (CVCL_II85)

Cross-references
Cell line name	BIONi010-C-6
Synonyms	BIONi010-C ApoE E2/E2
Accession	CVCL_II85
Resource Identification Initiative	To cite this cell line use: BIONi010-C-6 (RRID:CVCL_II85)
Comments	From: Bioneer A/S; Horsholm; Denmark. Population: African. Omics: Genomics; Whole genome sequencing. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:613; APOE; Simple_edited; p.Arg176Cys (c.526C>T); ClinVar=VCV000017848; Zygosity=Hemizygous; Note=By CRISPR/Cas9. ApoE2 allele. The second allele is disrupted by a 3.4 kb insertion from the selection plasmid (PubMed=30660866; PubMed=32971461).
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1E68 (BIONi010-C)
Sex of cell	Male
Age at sampling	18Y
Category	Induced pluripotent stem cell
Publications	PubMed=30660866; DOI=10.1016/j.scr.2018.11.010 Benjamin Schmid, Kennie Rosairus Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Bekker Poulsen, Ida Jorring, Mikkel Aabech Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi S. Muddashetty ...Show all 17 authors... , Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjorn Holst, Alfredo Cabrera-Socorro; Show fewer authors Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line. Stem Cell Res. 34:101349-101349(2019) PubMed=32971461; DOI=10.1016/j.scr.2020.102005 Benjamin Schmid, Kennie Rosairus Prehn, Natakarn Nimsanor, Blanca Irene Aldana Garcia, Ulla Bekker Poulsen, Ida Jorring, Mikkel Aabech Rasmussen, Christian Clausen, Ulrike A. Mau-Holzmann, Sarayu Ramakrishna, Ravi S. Muddashetty ...Show all 17 authors... , Rachel Steeg, Kevin Bruce, Peter Mackintosh, Andreas Ebneth, Bjorn Holst, Alfredo Cabrera-Socorro; Show fewer authors Corrigendum to 'Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line' [Stem Cell Res. 34/1873-5061 (2019) 101349-55]. Stem Cell Res. 48:102005-102005(2020)
Cell line collections (Providers)	EBiSC; BIONi010-C-6 ECACC; 66540368 - Discontinued
Cell line databases/resources	hPSCreg; BIONi010-C-6 SKIP; SKIP002861
Biological sample resources	BioSamples; SAMEA4454009
Encyclopedic resources	Wikidata; Q54796778
Sequence databases	EGA; EGAS00001002755
Entry history
Entry creation	01-Dec-2016
Last entry update	10-Apr-2025
Version number	18