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Cellosaurus BIONi010-C-4 (CVCL_II83)

[Text version]
Cell line name BIONi010-C-4
Synonyms BIONi010-C ApoE E4/E4 #B44 P27
Accession CVCL_II83
Resource Identification Initiative To cite this cell line use: BIONi010-C-4 (RRID:CVCL_II83)
Comments From: Bioneer A/S; Horsholm; Denmark.
Population: African.
Omics: Genome sequenced.
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; 613; APOE; Simple_edited; p.Cys130Arg (c.388T>C); ClinVar=VCV000017864; Zygosity=Hemizygous; Note=ApoE4 allele. By CRISPR/Cas9. The second allele is disrupted by a 5.4 kb insertion from the selection plasmid (PubMed=30660866; PubMed=32971461).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1E68 (BIONi010-C)
Sex of cell Male
Age at sampling 18Y
Category Induced pluripotent stem cell
Publications

PubMed=30660866; DOI=10.1016/j.scr.2018.11.010
Schmid B., Prehn K.R., Nimsanor N., Aldana Garcia B.I., Poulsen U.B., Jorring I., Rasmussen M.A., Clausen C., Mau-Holzmann U.A., Ramakrishna S., Muddashetty R.S., Steeg R., Bruce K., Mackintosh P., Ebneth A., Holst B., Cabrera-Socorro A.
Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line.
Stem Cell Res. 34:101349-101349(2019)

PubMed=32971461; DOI=10.1016/j.scr.2020.102005
Schmid B., Prehn K.R., Nimsanor N., Aldana Garcia B.I., Poulsen U.B., Jorring I., Rasmussen M.A., Clausen C., Mau-Holzmann U.A., Ramakrishna S., Muddashetty R.S., Steeg R., Bruce K., Mackintosh P., Ebneth A., Holst B., Cabrera-Socorro A.
Corrigendum to 'Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line' [Stem Cell Res. 34/1873-5061 (2019) 101349-55].
Stem Cell Res. 48:102005-102005(2020)

Cross-references
Cell line collections (Providers) EBiSC; BIONi010-C-4
ECACC; 66540366 - Discontinued
Cell line databases/resources hPSCreg; BIONi010-C-4
SKIP; SKIP002853
Biological sample resources BioSamples; SAMEA4452060
Encyclopedic resources Wikidata; Q54796774
Sequence databases EGA; EGAS00001002755
Entry history
Entry creation01-Dec-2016
Last entry update30-Jan-2024
Version number14