Cellosaurus logo
expasy logo

Cellosaurus S_N40R2 (CVCL_HG10)

[Text][XML][JSON]
Cell line name S_N40R2
Accession CVCL_HG10
Resource Identification Initiative To cite this cell line use: S_N40R2 (RRID:CVCL_HG10)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_46742; Nutlin-3.
Derived from site: In situ; Bone, femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1697 (SJSA-1)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): ECACC=17011210

Markers:
AmelogeninX,Y
CSF1PO7.3,10.1
D3S135816,17
D5S81812
D7S8209,11
D8S117913,15
D13S31712
D16S5399,10
D18S5115,17
D21S1128,33.2
FGA22,23
Penta D2.2,10
Penta E11,14
TH017,9
TPOX8,9
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=27323823; DOI=10.18632/oncotarget.10073; PMCID=PMC5216791
Catherine J. Drummond, Arman Esfandiari, Jun-Feng Liu, Xiao-Hong Lu, Claire Hutton, Jennifer Jackson, Karim Bennaceur, Qing Xu, Aditya Rao Makimanejavali, Fabio Del Bello, Alessandro Piergentili ...Show all 15 authors... , David R. Newell, Ian Robert Hardcastle, Roger J. Griffin, John Lunec; Show fewer authors
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
Oncotarget 7:46203-46218(2016)

Cross-references
Cell line collections (Providers) CancerTools; 152838
ECACC; 17011210 - Discontinued
Ximbio; 152838
Cell line databases/resources cancercelllines; CVCL_HG10
Encyclopedic resources Wikidata; Q54951556
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number17