ID   S_N40R2
AC   CVCL_HG10
DR   cancercelllines; CVCL_HG10
DR   CancerTools; 152838
DR   ECACC; 17011210
DR   Wikidata; Q54951556
DR   Ximbio; 152838
RX   PubMed=27323823;
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI:46742; Nutlin-3.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Bone, femur; UBERON=UBERON_0000981.
ST   Source(s): ECACC
ST   Amelogenin: X,Y
ST   CSF1PO: 7.3,10.1
ST   D13S317: 12
ST   D16S539: 9,10
ST   D18S51: 15,17
ST   D21S11: 28,33.2
ST   D3S1358: 16,17
ST   D5S818: 12
ST   D7S820: 9,11
ST   D8S1179: 13,15
ST   FGA: 22,23
ST   Penta D: 2.2,10
ST   Penta E: 11,14
ST   TH01: 7,9
ST   TPOX: 8,9
ST   vWA: 19
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1697 ! SJSA-1
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 14
//
RX   PubMed=27323823; DOI=10.18632/oncotarget.10073;
RA   Drummond C.J., Esfandiari A., Liu J.-F., Lu X.-H., Hutton C.,
RA   Jackson J., Bennaceur K., Xu Q., Makimanejavali A.R., Del Bello F.,
RA   Piergentili A., Newell D.R., Hardcastle I.R., Griffin R.J., Lunec J.;
RT   "TP53 mutant MDM2-amplified cell lines selected for resistance to
RT   MDM2-p53 binding antagonists retain sensitivity to ionizing
RT   radiation.";
RL   Oncotarget 7:46203-46218(2016).
//