| Cell line name |
NCI-H1975/GR |
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| Accession |
CVCL_HF59 |
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| Resource Identification Initiative |
To cite this cell line use: NCI-H1975/GR (RRID:CVCL_HF59) |
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| Comments |
Population: Caucasian.
Doubling time: 47.73 +- 3.50 hours (PubMed=25008024); 46.535 +- 0.428 hours (PubMed=25483995).
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
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| Sequence variations |
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Lung adenocarcinoma (NCIt: C3512) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1511 (NCI-H1975)
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=25008024; DOI=10.1007/s10735-014-9583-2
Jing Wang, Hong Wei, Bao-Xia Zhao, Mei Li, Wei-Peng Lv, Ling Lv, Bo Song, Shen Lv;
The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro.
J. Mol. Histol. 45:641-652(2014) PubMed=25483995; DOI=10.3892/mmr.2014.3058
Bao-Xia Zhao, Jing Wang, Bo Song, Hong Wei, Wei-Peng Lv, Li-Min Tian, Mei Li, Shen Lv;
Establishment and biological characteristics of acquired gefitinib resistance in cell line NCI-H1975/gefinitib-resistant with epidermal growth factor receptor T790M mutation.
Mol. Med. Rep. 11:2767-2774(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_HF59
|
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| Encyclopedic resources |
Wikidata; Q54907894
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 13 |
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