ID   NCI-H1975/GR
AC   CVCL_HF59
DR   cancercelllines; CVCL_HF59
DR   Wikidata; Q54907894
RX   PubMed=25008024;
RX   PubMed=25483995;
CC   Population: Caucasian.
CC   Doubling time: 47.73 +- 3.50 hours (PubMed=25008024); 46.535 +- 0.428 hours (PubMed=25483995).
CC   Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1511 ! NCI-H1975
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 12
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RX   PubMed=25008024; DOI=10.1007/s10735-014-9583-2;
RA   Wang J., Wei H., Zhao B.-X., Li M., Lv W.-P., Lv L., Song B., Lv S.;
RT   "The reverse effect of X-ray irradiation on acquired gefitinib
RT   resistance in non-small cell lung cancer cell line NCI-H1975 in
RT   vitro.";
RL   J. Mol. Histol. 45:641-652(2014).
//
RX   PubMed=25483995; DOI=10.3892/mmr.2014.3058;
RA   Zhao B.-X., Wang J., Song B., Wei H., Lv W.-P., Tian L.-M., Li M.,
RA   Lv S.;
RT   "Establishment and biological characteristics of acquired gefitinib
RT   resistance in cell line NCI-H1975/gefinitib-resistant with epidermal
RT   growth factor receptor T790M mutation.";
RL   Mol. Med. Rep. 11:2767-2774(2015).
//