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Cellosaurus (CVCL_HE51)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Doubling time: 48 hours (PubMed=25984343); ~40 hours (CLS=300127); ~35 hours (DSMZ=ACC-255).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Caution: Was incorrectly indicated to have an EWSR1-FLI1 (EWS-FLI1) gene fusion in PubMed=23637631.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
HLA typing Source: PubMed=26589293
Class I
HLA-AA*11:01,24:02
HLA-BB*15:01,40:01
HLA-CC*04:01,07:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.63
Native American0.72
East Asian, North75.38
East Asian, South21.78
South Asian0
European, North0
European, South0.48
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_HE52 (CAK-B3-Toyr13)
Sex of cell Female
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): CLS=300127; Cosmic-CLP=753539; DSMZ=ACC-255; PubMed=19787792; PubMed=30879952

Markers:

Run an STR similarity search on this cell line
Publications



copies by micronucleus formation -- sign of tumour cell revertance?
Eur. J. Cancer 33:2043-2049(1997)


Rekha V. Iyengar, Erik J. Krull, Stephen E. Mason, Ruchi Khanna, Linda C. Harris, Philip M. Potter, Mary K. Danks, Sylvie M. Guichard;
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11.
Mol. Ther. 1:457-463(2000)


Jia-Kun Zheng, Ge Huang, Tian-Hua Huang, Gui-Zhi Ju;
A novel mutated cell line with characteristics of dedifferentiated chondrosarcoma.
Int. J. Mol. Med. 24:427-435(2009)


Hangnoh Lee, Charles Joel McManus, Dong-Yeon Cho, Matthew Eaton, Fioranna Renda, Maria Patrizia Somma, Lucy Cherbas, Gemma May, Sara Powell, Da-Yu Zhang, Li-Jun Zhan ...Show all 20 authors... , Alissa Resch, Justen Andrews, Susan E. Celniker, Peter Cherbas, Teresa Maria Przytycka, Maurizio Gatti, Brian Oliver, Brenton R. Graveley, David M. MacAlpine; Show fewer authors
DNA copy number evolution in Drosophila cell lines.
Genome Biol. 15:R70.1-R70.20(2014)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)


Jenny Worthington, Tassja J. Spindler, Darragh O'Brien, Janet M. Lee, Georgia Spain, Maryam Sharifian, Gui-Song Wang, Kathleen M. Darcy, Tanja Pejovic, Heidi M. Sowter, John F. Timms, Simon Andrew Gayther;
Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis.
Int. J. Cancer 137:1806-1817(2015)


Yu Wang, Zhen Wu, Jun-Ting Zhang, Zhao-Hui Wang, Rui Yang, Jenna Lewis, Darell Doty Bigner, Fang-Ping Zhao, Yi-Ping He, Hai Yan, Qin Shen, Li-Wei Zhang;
Patient-derived DIPG cells preserve stem-like characteristics and generate orthotopic tumors.
Oncotarget 8:76644-76655(2017)



literature.
Cancer Res. 77:2784-2788(2017)


Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Hiroaki Magotani, Hirotaka Onoe, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Ryosuke Takahashi, Haruhisa Inoue, Satoshi Morita ...Show all 16 authors... , Michio Yamamoto, Keisuke Okita, Masato Nakagawa, Malin Parmar, Jun Takahashi; Show fewer authors
Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model.
Nature 548:592-596(2017)




Cancer Cell 33:386-400.e5(2018)


Katsushi Tokunaga, Masao Nagasaki, Seiji Kito, Keiichi Isoyama, Masafumi Onodera, Hideo Kaneko, Naomichi Matsumoto, Fumihiko Matsuda, Keitaro Matsuo, Yoshiyuki Takahashi, Tomoji Mashimo ...Show all 13 authors... , Seiji Kojima, Tomoo Ogi; Show fewer authors
Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.
Sci. Adv. 6:eabd7197.1-eabd7197.15(2020)

Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number37