Cellosaurus cell line GEM-MIA PaCa-2 (CVCL

Cross-references
Cell line name	GEM-MIA PaCa-2
Synonyms	GEM,MIA PaCa-2
Accession	CVCL_HA89
Resource Identification Initiative	To cite this cell line use: GEM-MIA PaCa-2 (RRID:CVCL_HA89)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_175901; Gemcitabine (Gemzar). Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations	Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Cys (c.34G>T); ClinVar=VCV000012578; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (from parent cell line).
Disease	Pancreatic undifferentiated carcinoma (NCIt: C5722)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0428 (MIA PaCa-2)
Sex of cell	Male
Age at sampling	65Y
Category	Cancer cell line
Publications	PubMed=14508125; DOI=10.1097/00006676-200310000-00004 Akira Togawa, Hiroshi Ito, Fumio Kimura, Hiroaki Shimizu, Masayuki Ohtsuka, Fumihiko Shimamura, Hiroyuki Yoshidome, Astushi Katoh, Masaru Miyazaki; Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of brefeldin-a on the resistant cell line. Pancreas 27:220-224(2003)
Cell line databases/resources	cancercelllines; CVCL_HA89
Encyclopedic resources	Wikidata; Q54835559
Entry history
Entry creation	01-Dec-2016
Last entry update	19-Dec-2024
Version number	13