Cellosaurus cell line CF/T43 (CVCL

Cellosaurus CF/T43 (CVCL_HA79)

Cross-references
Cell line name	CF/T43
Synonyms	CF-T43; CFT43
Accession	CVCL_HA79
Resource Identification Initiative	To cite this cell line use: CF/T43 (RRID:CVCL_HA79)
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pZIPneoSV(X)1/SV40T). Derived from site: In situ; Nose, nasal cavity, epithelium; UBERON=UBERON_0005384. Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Transformed cell line
Publications	PubMed=2472008; DOI=10.1126/science.2472008 Anton M. Jetten, James Robert Yankaskas, Monroe Jackson Stutts, Niels J. Willumsen, Richard C. Boucher; Persistence of abnormal chloride conductance regulation in transformed cystic fibrosis epithelia. Science 244:1472-1475(1989) PubMed=8755664; DOI=10.1172/JCI118819; PMCID=PMC507457 Thomas J. Kelley, Layla Al-Nakkash, Calvin U. Cotton, Mitchell L. Drumm; Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition. J. Clin. Invest. 98:513-520(1996) PubMed=9277448; DOI=10.1152/ajplung.1997.273.2.L363 Robert A. Harris, Douglas J. Pon, Sidney Katz, John W. Hanrahan; Intracellular calcium responses in CF/T43 cells: calcium pools and influx pathways. Am. J. Physiol. 273:L363-L373(1997) PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040 Dieter C. Gruenert, Marjolaine Willems, Jean-Jacques Cassiman, Raymond A. Frizzell; Established cell lines used in cystic fibrosis research. J. Cyst. Fibros. 3:191-196(2004)
Encyclopedic resources	Wikidata; Q54811356
Entry history
Entry creation	01-Dec-2016
Last entry update	14-Aug-2025
Version number	15