ID   CF/T43
AC   CVCL_HA79
SY   CF-T43; CFT43
DR   Wikidata; Q54811356
RX   PubMed=2472008;
RX   PubMed=8755664;
RX   PubMed=9277448;
RX   PubMed=15463957;
CC   Sequence variation: Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=pZIPneoSV(X)1/SV40T].
CC   Derived from site: In situ; Nose, nasal cavity, epithelium; UBERON=UBERON_0005384.
CC   Cell type: Epithelial cell; CL=CL_0000066.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 01-12-16; Last updated: 05-10-23; Version: 12
//
RX   PubMed=2472008; DOI=10.1126/science.2472008;
RA   Jetten A.M., Yankaskas J.R., Stutts M.J., Willumsen N.J.,
RA   Boucher R.C.;
RT   "Persistence of abnormal chloride conductance regulation in
RT   transformed cystic fibrosis epithelia.";
RL   Science 244:1472-1475(1989).
//
RX   PubMed=8755664; DOI=10.1172/JCI118819;
RA   Kelley T.J., Al-Nakkash L., Cotton C.U., Drumm M.L.;
RT   "Activation of endogenous deltaF508 cystic fibrosis transmembrane
RT   conductance regulator by phosphodiesterase inhibition.";
RL   J. Clin. Invest. 98:513-520(1996).
//
RX   PubMed=9277448; DOI=10.1152/ajplung.1997.273.2.L363;
RA   Harris R.A., Pon D.J., Katz S., Hanrahan J.W.;
RT   "Intracellular calcium responses in CF/T43 cells: calcium pools and
RT   influx pathways.";
RL   Am. J. Physiol. 273:L363-L373(1997).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//