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Cellosaurus Mac-2A (CVCL_H637)

[Text version]
Cell line name Mac-2A
Synonyms MAC-2A; MAC2A; McG-2A; PB-2A
Accession CVCL_H637
Resource Identification Initiative To cite this cell line use: Mac-2A (RRID:CVCL_H637)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Donor information: Originally the patient was suffering from Hodgkin lymphoma.
Disease Anaplastic large cell lymphoma, ALK-negative (NCIt: C37194)
ALK-negative anaplastic large cell lymphoma (ORDO: Orphanet_300903)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_H632 (Mac-2)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line

Su I.-J., Kadin M.E.
Expression of growth factor/receptor genes in postthymic T cell malignancies.
Am. J. Pathol. 135:439-445(1989)

PubMed=1532439; DOI=10.1056/NEJM199204233261704
Davis T.H., Morton C.C., Miller-Cassman R., Balk S.P., Kadin M.E.
Hodgkin's disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone.
N. Engl. J. Med. 326:1115-1122(1992)

PubMed=9162223; DOI=10.1006/cyto.1996.0044
Marti R.M., Wasik M.A., Kadin M.E.
Constitutive secretion of GM-CSF by three different cell lines derived from a single patient with a progressive cutaneous lymphoproliferative disorder.
Cytokine 8:323-329(1996)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15356658; DOI=10.1038/sj.leu.2403465
Drexler H.G., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.
Leukemia 18:1569-1571(2004)

PubMed=28356514; DOI=10.1073/pnas.1700682114
Chen J., Zhang Y., Petrus M.N., Xiao W.-M., Nicolae A., Raffeld M., Pittaluga S., Bamford R.N., Nakagawa M., Ouyang S.T.-Y., Epstein A.L., Kadin M.E., Del Mistro A., Woessner R.D., Jaffe E.S., Waldmann T.A.
Cytokine receptor signaling is required for the survival of ALK- anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations.
Proc. Natl. Acad. Sci. U.S.A. 114:3975-3980(2017)

PubMed=29533902; DOI=10.1515/hsz-2017-0321
Drexler H.G., Pommerenke C., Eberth S., Nagel S.
Hodgkin lymphoma cell lines: to separate the wheat from the chaff.
Biol. Chem. 399:511-523(2018)

Cell line databases/resources Cell_Model_Passport; SIDM01361
DepMap; ACH-001119
Encyclopedic resources Wikidata; Q54903949
Gene expression databases GEO; GSM2527946
Polymorphism and mutation databases Cosmic; 2814457
Entry history
Entry creation11-Feb-2013
Last entry update21-Mar-2023
Version number13