Cellosaurus cell line MeT-4A (CVCL

Cellosaurus MeT-4A (CVCL_H531)

Cross-references
Cell line name	MeT-4A
Synonyms	MeT 4A; Met4A; Mesothelial cells transfected with pRSV-T 4A
Accession	CVCL_H531
Resource Identification Initiative	To cite this cell line use: MeT-4A (RRID:CVCL_H531)
Comments	Characteristics: Cell line positive for alternative lengthening of telomeres (ALT+) (CelloPub=CLPUB00712; PubMed=19935656). Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T). Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977. Cell type: Mesothelial cell; CL=CL_0000077.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category	Transformed cell line
Publications	PubMed=2541616; PMCID=PMC1879894 Yang Ke, Roger Robert Reddel, Brenda Isen Gerwin, Helen K. Reddel, Angela N.A. Somers, Mary G. McMenamin, Moira A. LaVeck, Rolf A. Stahel, John F. Lechner, Curtis Craig Harris; Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am. J. Pathol. 134:979-991(1989) PubMed=9175740; DOI=10.1093/hmg/6.6.921 Tracy M. Bryan, Lidija Marusic, Silvia Bacchetti, Masayoshi Namba, Roger Robert Reddel; The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit. Hum. Mol. Genet. 6:921-926(1997) CLPUB00712 Jeremy David Henson; The role of alternative lengthening of telomeres in human cancer. Thesis PhD (2006); University of Sydney; Sydney; Australia PubMed=19935656; DOI=10.1038/nbt.1587 Jeremy David Henson, Ying Cao, Lily I. Huschtscha, Andy C.-M. Chang, Amy Y.M. Au, Hilda A. Pickett, Roger Robert Reddel; DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity. Nat. Biotechnol. 27:1181-1185(2009)
Encyclopedic resources	Wikidata; Q54905321
Entry history
Entry creation	11-Feb-2013
Last entry update	14-Aug-2025
Version number	13