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Cellosaurus BRI-JM01 (CVCL_H218)

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Cell line name BRI-JM01
Accession CVCL_H218
Resource Identification Initiative To cite this cell line use: BRI-JM01 (RRID:CVCL_H218)
Comments Characteristics: Can be used to study TGFbeta-induced epithelial-to-mesenchymal transition (EMT). Did not maintain expression of the activated Neu oncogene and lost the Tgfbr2 sequence (PubMed=15318933).
Doubling time: 14 hours (PubMed=15318933).
Genetic integration: Method=Transgenic mouse; Gene=RGD; 2561; Erbb2 (Note=With p.Val661Glu).
Transformant: Activated Erbb2/neu.
Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
Disease Malignant neoplasms of the mouse mammary gland (NCIt: C21678)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: FVB MMTV/activated Neu, Tgfbr2-AS transgenic.
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=15318933; DOI=10.1186/bcr907; PMCID=PMC549171
Anne E.G. Lenferink, Joanne Magoon, Christiane Cantin, Maureen D. O'Connor-McCourt;
Investigation of three new mouse mammary tumor cell lines as models for transforming growth factor (TGF)-beta and Neu pathway signaling studies: identification of a novel model for TGF-beta-induced epithelial-to-mesenchymal transition.
Breast Cancer Res. 6:R514-R530(2004)

Cross-references
Encyclopedic resources Wikidata; Q54798233
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number9