ID   BRI-JM01
AC   CVCL_H218
DR   Wikidata; Q54798233
RX   PubMed=15318933;
CC   Characteristics: Can be used to study TGFbeta-induced epithelial-to-mesenchymal transition (EMT). Did not maintain expression of the activated Neu oncogene and lost the Tgfbr2 sequence (PubMed=15318933).
CC   Doubling time: 14 hours (PubMed=15318933).
CC   Genetic integration: Method=Transgenic mouse; Gene=RGD; 2561; Erbb2 (Note=With p.Val661Glu).
CC   Transformant: Activated Erbb2/neu.
CC   Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
CC   Breed/subspecies: FVB MMTV/activated Neu, Tgfbr2-AS transgenic.
DI   NCIt; C21678; Malignant neoplasms of the mouse mammary gland
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 8
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RX   PubMed=15318933; DOI=10.1186/bcr907; PMCID=PMC549171;
RA   Lenferink A.E.G., Magoon J., Cantin C., O'Connor-McCourt M.D.;
RT   "Investigation of three new mouse mammary tumor cell lines as models
RT   for transforming growth factor (TGF)-beta and Neu pathway signaling
RT   studies: identification of a novel model for TGF-beta-induced
RT   epithelial-to-mesenchymal transition.";
RL   Breast Cancer Res. 6:R514-R530(2004).
//