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Cellosaurus HMC-1.1 (CVCL_H206)

[Text version]
Cell line name HMC-1.1
Synonyms HMC-1_1; HMC1.1; HMC-1(560); HMC-1-560
Accession CVCL_H206
Resource Identification Initiative To cite this cell line use: HMC-1.1 (RRID:CVCL_H206)
Comments Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Mast cell; CL=CL_0000097.
Sequence variations
Disease Mast cell leukemia (NCIt: C3169)
Mast cell leukemia (ORDO: Orphanet_98851)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0003 (HMC-1)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC067

Markers:
AmelogeninX
CSF1PO10,13
D3S135815
D5S81812,13
D7S82010,11
D8S117912
D13S31711
D16S53910,12
D18S5114,20
D21S1129
FGA18,20
Penta D11
Penta E9,19
TH017,9.3
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=11861291; DOI=10.1182/blood.V99.5.1741
Ma Y.-S., Zeng S., Metcalfe D.D., Akin C., Dimitrijevic S., Butterfield J.H., McMahon G., Longley B.J.
The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations.
Blood 99:1741-1744(2002)

PubMed=12519307; DOI=10.1046/j.1365-2567.2003.01559.x; PMCID=PMC1782858
Sundstrom M., Vliagoftis H., Karlberg P., Butterfield J.H., Nilsson K., Metcalfe D.D., Nilsson G.
Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene.
Immunology 108:89-97(2003)

PubMed=20814942; DOI=10.1002/0471142735.im0737s90; PMCID=PMC2923748
Radinger M., Jensen B.M., Kuehn H.S., Kirshenbaum A.S., Gilfillan A.M.
Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood.
Curr. Protoc. Immunol. 90:7.37.1-7.37.12(2010)

PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8
Passante E.
Mast cell and basophil cell lines: a compendium.
Methods Mol. Biol. 1192:101-113(2014)

PubMed=37025992; DOI=10.3389/fimmu.2023.1078958; PMCID=PMC10071028
Bandara G., Falduto G.H., Luker A.J., Bai Y., Pfeiffer A., Lack J.B., Metcalfe D.D., Olivera A.
CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell line with a single D816V-KIT mutation: an improved preclinical model for research on mastocytosis.
Front. Immunol. 14:1078958.1-1078958.17(2023)

Cross-references
Cell line collections (Providers) Millipore; SCC067
Cell line databases/resources cancercelllines; CVCL_H206
Encyclopedic resources Wikidata; Q54889909
Gene expression databases GEO; GSM6674134
GEO; GSM6674135
GEO; GSM6674136
Polymorphism and mutation databases Cosmic; 819947
Cosmic; 1476309
Cosmic; 1476421
Cosmic; 1498491
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number18