ID   HMC-1.1
AC   CVCL_H206
SY   HMC-1_1; HMC1.1; HMC-1(560); HMC-1-560
DR   cancercelllines; CVCL_H206
DR   Cosmic; 819947
DR   Cosmic; 1476309
DR   Cosmic; 1476421
DR   Cosmic; 1498491
DR   GEO; GSM6674134
DR   GEO; GSM6674135
DR   GEO; GSM6674136
DR   Millipore; SCC067
DR   Wikidata; Q54889909
RX   PubMed=11861291;
RX   PubMed=12519307;
RX   PubMed=20814942;
RX   PubMed=25149487;
RX   PubMed=37025992;
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560Gly (c.1679T>G); ClinVar=VCV000375916; Zygosity=Heterozygous (PubMed=12519307).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: Mast cell; CL=CL_0000097.
ST   Source(s): Millipore=SCC067
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 11
ST   D16S539: 10,12
ST   D18S51: 14,20
ST   D21S11: 29
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 10,11
ST   D8S1179: 12
ST   FGA: 18,20
ST   Penta D: 11
ST   Penta E: 9,19
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 19
DI   NCIt; C3169; Mast cell leukemia
DI   ORDO; Orphanet_98851; Mast cell leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0003 ! HMC-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 18
//
RX   PubMed=20814942; DOI=10.1002/0471142735.im0737s90; PMCID=PMC2923748;
RA   Radinger, Madeleine
RA   Jensen, Bettina Margrethe
RA   Kuehn, Hye Sun
RA   Kirshenbaum, Arnold S.
RA   Gilfillan, Alasdair M.
RT   "Generation, isolation, and maintenance of human mast cells and mast
RT   cell lines derived from peripheral blood or cord blood.";
RL   Curr. Protoc. Immunol. 90:7.37.1-7.37.12(2010).
//
RX   PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8;
RA   Passante, Egle
RT   "Mast cell and basophil cell lines: a compendium.";
RL   Methods Mol. Biol. 1192:101-113(2014).
//
RX   PubMed=37025992; DOI=10.3389/fimmu.2023.1078958; PMCID=PMC10071028;
RA   Bandara, Geethani
RA   Falduto, Guido H.
RA   Luker, Andrea J.
RA   Bai, Yun
RA   Pfeiffer, Annika
RA   Lack, Justin B.
RA   Metcalfe, Dean D.
RA   Olivera, Ana
RT   "CRISPR/Cas9-engineering of HMC-1.2 cells renders a human mast cell
RT   line with a single D816V-KIT mutation: an improved preclinical model
RT   for research on mastocytosis.";
RL   Front. Immunol. 14:1078958.1-1078958.17(2023).
//
RX   PubMed=12519307; DOI=10.1046/j.1365-2567.2003.01559.x; PMCID=PMC1782858;
RA   Sundstrom, Magnus
RA   Vliagoftis, Harissios
RA   Karlberg, Peter
RA   Butterfield, Joseph H.
RA   Nilsson, Kenneth
RA   Metcalfe, Dean D.
RA   Nilsson, Gunnar
RT   "Functional and phenotypic studies of two variants of a human mast
RT   cell line with a distinct set of mutations in the c-kit
RT   proto-oncogene.";
RL   Immunology 108:89-97(2003).
//
RX   PubMed=11861291; DOI=10.1182/blood.V99.5.1741;
RA   Ma, Yong-Sheng
RA   Zeng, Shan
RA   Metcalfe, Dean D.
RA   Akin, Cem
RA   Dimitrijevic, Sasa
RA   Butterfield, Joseph H.
RA   McMahon, Gerald
RA   Longley, B. Jack
RT   "The c-KIT mutation causing human mastocytosis is resistant to STI571
RT   and other KIT kinase inhibitors; kinases with enzymatic site mutations
RT   show different inhibitor sensitivity profiles than wild-type kinases
RT   and those with regulatory-type mutations.";
RL   Blood 99:1741-1744(2002).
//