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Cellosaurus YUHEF (CVCL_G326)

[Text version]
Cell line name YUHEF
Accession CVCL_G326
Resource Identification Initiative To cite this cell line use: YUHEF (RRID:CVCL_G326)
Comments Part of: Yale University (YU) melanoma cell collection.
Population: Caucasian.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Donor information: Established from the lung metastatic melanoma cells of Robert V. Heffernan (the 'HEF' in the cell name) who wrote about his successful fight against cancer in an autobiographical book (CelloPub=CLPUB00386).
Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
Sequence variations
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x; PMCID=PMC2848976
Ruth Halaban, Wen-Geng Zhang, Antonella Bacchiocchi, Elaine Cheng, Fabio Parisi, Stephan Ariyan, Michael Krauthammer, James Patricia McCusker, Yuval Kluger, Mario Sznol;
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.
Pigment Cell Melanoma Res. 23:190-200(2010)

PubMed=21521745; DOI=10.1158/1541-7786.MCR-10-0512; PMCID=PMC3117976
Kathryn Tworkoski, Garima Singhal, Sebastian Szpakowski, Christina Ivins Zito, Antonella Bacchiocchi, Viswanathan Muthusamy, Marcus W. Bosenberg, Michael Krauthammer, Ruth Halaban, David F. Stern;
Phosphoproteomic screen identifies potential therapeutic targets in melanoma.
Mol. Cancer Res. 9:801-812(2011)

PubMed=21543894; DOI=10.4161/cc.10.11.15777; PMCID=PMC3233487
Elcie Chan, Rajeshvari Patel, Sunitha Nallur, Elena Ratner, Antonella Bacchiocchi, Kathleen Hoyt, Sebastian Szpakowski, Sirie E. Godshalk, Stephan Ariyan, Mario Sznol, Ruth Halaban ...Show all 15 authors... , Michael Krauthammer, David Tuck, Frank J. Slack, Joanne Barnes Weidhaas; Show fewer authors
MicroRNA signatures differentiate melanoma subtypes.
Cell Cycle 10:1845-1852(2011)

PubMed=22842228; DOI=10.1038/ng.2359; PMCID=PMC3432702
Michael Krauthammer, Yong Kong, Byung Hak Ha, Perry Evans, Antonella Bacchiocchi, James Patricia McCusker, Elaine Cheng, Matthew J. Davis, Gerald Goh, Murim Choi, Stephan Ariyan ...Show all 30 authors... , Deepak Narayan, Ken Dutton-Regester, Ana Capatana, Edna C. Holman, Marcus W. Bosenberg, Mario Sznol, Harriet Margot Kluger, Douglas E. Brash, David F. Stern, Miguel Angel Materin, Roger S. Lo, Shrikant M. Mane, Shuang-Ge Ma, Kenneth Kay Kidd, Nicholas K. Hayward, Richard Priestley Lifton, Joseph Schlessinger, Titus J. Boggon, Ruth Halaban; Show fewer authors
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat. Genet. 44:1006-1014(2012)

CLPUB00386
Robert V. Heffernan;
Cancer's gifts with love & hope.
(In book) ISBN 9781475990607; pp.1-196; iUniverse; Bloomington; USA (2013)

PubMed=26214590; DOI=10.1038/ng.3361; PMCID=PMC4916843
Michael Krauthammer, Yong Kong, Antonella Bacchiocchi, Perry Evans, Natapol Pornputtapong, Cen Wu, James Patricia McCusker, Shuang-Ge Ma, Elaine Cheng, Robert Straub, Merdan Serin ...Show all 20 authors... , Marcus W. Bosenberg, Stephan Ariyan, Deepak Narayan, Mario Sznol, Harriet Margot Kluger, Shrikant M. Mane, Joseph Schlessinger, Richard Priestley Lifton, Ruth Halaban; Show fewer authors
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Nat. Genet. 47:996-1002(2015)

Cross-references
Encyclopedic resources Wikidata; Q54995665
Polymorphism and mutation databases Cosmic; 1548857
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number20