ID   YUHEF
AC   CVCL_G326
DR   Cosmic; 1548857
DR   Wikidata; Q54995665
RX   CelloPub=CLPUB00386;
RX   PubMed=20149136;
RX   PubMed=21521745;
RX   PubMed=21543894;
RX   PubMed=22842228;
RX   PubMed=26214590;
CC   Part of: Yale University (YU) melanoma cell collection.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Gln853Ter (c.2557C>T); ClinVar=VCV001318665; Zygosity=Unspecified (PubMed=26214590).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Lys2552Thrfs*2; Zygosity=Unspecified (PubMed=26214590).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Donor information: Established from the lung metastatic melanoma cells of Robert V. Heffernan (the 'HEF' in the cell name) who wrote about his successful fight against cancer in an autobiographical book (CelloPub=CLPUB00386).
CC   Derived from site: Metastatic; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 20
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RX   CelloPub=CLPUB00386;
RA   Heffernan R.V.;
RT   "Cancer's gifts with love & hope.";
RL   (In book) ISBN 9781475990607; pp.1-196; iUniverse; Bloomington; USA (2013).
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RX   PubMed=20149136; DOI=10.1111/j.1755-148X.2010.00685.x; PMCID=PMC2848976;
RA   Halaban R., Zhang W., Bacchiocchi A., Cheng E., Parisi F., Ariyan S.,
RA   Krauthammer M., McCusker J.P., Kluger Y., Sznol M.;
RT   "PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK
RT   pathway and enhances cell migration and proliferation of BRAF melanoma
RT   cells.";
RL   Pigment Cell Melanoma Res. 23:190-200(2010).
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RX   PubMed=21521745; DOI=10.1158/1541-7786.MCR-10-0512; PMCID=PMC3117976;
RA   Tworkoski K., Singhal G., Szpakowski S., Zito C.I., Bacchiocchi A.,
RA   Muthusamy V., Bosenberg M.W., Krauthammer M., Halaban R., Stern D.F.;
RT   "Phosphoproteomic screen identifies potential therapeutic targets in
RT   melanoma.";
RL   Mol. Cancer Res. 9:801-812(2011).
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RX   PubMed=21543894; DOI=10.4161/cc.10.11.15777; PMCID=PMC3233487;
RA   Chan E., Patel R., Nallur S., Ratner E., Bacchiocchi A., Hoyt K.,
RA   Szpakowski S., Godshalk S.E., Ariyan S., Sznol M., Halaban R.,
RA   Krauthammer M., Tuck D., Slack F.J., Weidhaas J.B.;
RT   "MicroRNA signatures differentiate melanoma subtypes.";
RL   Cell Cycle 10:1845-1852(2011).
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RX   PubMed=22842228; DOI=10.1038/ng.2359; PMCID=PMC3432702;
RA   Krauthammer M., Kong Y., Ha B.H., Evans P., Bacchiocchi A.,
RA   McCusker J.P., Cheng E., Davis M.J., Goh G., Choi M., Ariyan S.,
RA   Narayan D., Dutton-Regester K., Capatana A., Holman E.C.,
RA   Bosenberg M.W., Sznol M., Kluger H.M., Brash D.E., Stern D.F.,
RA   Materin M.A., Lo R.S., Mane S.M., Ma S.-G., Kidd K.K., Hayward N.K.,
RA   Lifton R.P., Schlessinger J., Boggon T.J., Halaban R.;
RT   "Exome sequencing identifies recurrent somatic RAC1 mutations in
RT   melanoma.";
RL   Nat. Genet. 44:1006-1014(2012).
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RX   PubMed=26214590; DOI=10.1038/ng.3361; PMCID=PMC4916843;
RA   Krauthammer M., Kong Y., Bacchiocchi A., Evans P., Pornputtapong N.,
RA   Wu C., McCusker J.P., Ma S.-G., Cheng E., Straub R., Serin M.,
RA   Bosenberg M.W., Ariyan S., Narayan D., Sznol M., Kluger H.M., Mane S.M.,
RA   Schlessinger J., Lifton R.P., Halaban R.;
RT   "Exome sequencing identifies recurrent mutations in NF1 and RASopathy
RT   genes in sun-exposed melanomas.";
RL   Nat. Genet. 47:996-1002(2015).
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