Cellosaurus cell line CFT1 (CVCL

Cellosaurus CFT1 (CVCL_G214)

Cross-references
Cell line name	CFT1
Accession	CVCL_G214
Resource Identification Initiative	To cite this cell line use: CFT1 (RRID:CVCL_G214)
Comments	Group: Patented cell line. Doubling time: 36.3 hours (Note=At 14th passage) (PubMed=7684560). Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18) (Note=pUC19). Derived from site: In situ; Trachea; UBERON=UBERON_0003126.
Sequence variations	Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
Disease	Cystic fibrosis (NCIt: C2975) Cystic fibrosis (ORDO: Orphanet_586)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	24Y
Category	Transformed cell line
Publications	DOI=10.1007/978-1-4612-0411-4_17 Conrad M., Yankaskas J.R., Boucher R.C., Schlegel R. Using the papillomavirus E6/E7 genes to generate well-differentiated epithelial cell lines. (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.163-167; Humana Press; New York; USA (1990) PubMed=7684560; DOI=10.1152/ajpcell.1993.264.5.C1219 Yankaskas J.R., Haizlip J.E., Conrad M., Koval D., Lazarowski E., Paradiso A.M., Rinehart C.A. Jr., Sarkadi B., Schlegel R., Boucher R.C. Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype. Am. J. Physiol. 264:C1219-C1230(1993) Patent=US5576206 Schlegel R. Human papilloma virus genes and their use in gene therapy. Patent number US5576206, 19-Nov-1996 PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040 Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A. Established cell lines used in cystic fibrosis research. J. Cyst. Fibros. 3:191-196(2004)
Cell line collections (Providers)	Kerafast; ENC001 - Discontinued
Encyclopedic resources	Wikidata; Q54811462
Entry history
Entry creation	11-Feb-2013
Last entry update	19-Dec-2024
Version number	18