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Cellosaurus CFT1 (CVCL_G214)

[Text version]
Cell line name CFT1
Accession CVCL_G214
Resource Identification Initiative To cite this cell line use: CFT1 (RRID:CVCL_G214)
Comments Group: Patented cell line.
Doubling time: 36.3 hours (Note=At 14th passage) (PubMed=7684560).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18) [Note=pUC19].
Derived from site: In situ; Trachea; UBERON=UBERON_0003126.
Sequence variations
  • Mutation; HGNC; 1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
Disease Cystic fibrosis (NCIt: C2975)
Cystic fibrosis (ORDO: Orphanet_586)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 24Y
Category Transformed cell line
Publications

DOI=10.1007/978-1-4612-0411-4_17
Conrad M., Yankaskas J.R., Boucher R.C., Schlegel R.
Using the papillomavirus E6/E7 genes to generate well-differentiated epithelial cell lines.
(In) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.163-167; Humana Press; New York (1990)

PubMed=7684560; DOI=10.1152/ajpcell.1993.264.5.C1219
Yankaskas J.R., Haizlip J.E., Conrad M., Koval D., Lazarowski E., Paradiso A.M., Rinehart C.A. Jr., Sarkadi B., Schlegel R., Boucher R.C.
Papilloma virus immortalized tracheal epithelial cells retain a well-differentiated phenotype.
Am. J. Physiol. 264:C1219-C1230(1993)

Patent=US5576206
Schlegel R.
Human papilloma virus genes and their use in gene therapy.
Patent number US5576206, 19-Nov-1996

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

Cross-references
Cell line collections (Providers) Kerafast; ENC001
Encyclopedic resources Wikidata; Q54811462
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number16