ID   CFT1
AC   CVCL_G214
DR   Kerafast; ENC001
DR   Wikidata; Q54811462
RX   DOI=10.1007/978-1-4612-0411-4_17;
RX   Patent=US5576206;
RX   PubMed=7684560;
RX   PubMed=15463957;
CC   Group: Patented cell line.
CC   Doubling time: 36.3 hours (Note=At 14th passage) (PubMed=7684560).
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Homozygous (PubMed=15463957).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18) (Note=pUC19).
CC   Discontinued: Kerafast; ENC001; true.
CC   Derived from site: In situ; Trachea; UBERON=UBERON_0003126.
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   24Y
CA   Transformed cell line
DT   Created: 11-02-13; Last updated: 19-12-24; Version: 18
//
RX   DOI=10.1007/978-1-4612-0411-4_17;
RA   Conrad, Melissa
RA   Yankaskas, James Robert
RA   Boucher, Richard C.
RA   Schlegel, Richard
RT   "Using the papillomavirus E6/E7 genes to generate well-differentiated
RT   epithelial cell lines.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim, Johng Sik & Dritschilo, Anatoly (eds.); pp.163-167; Humana Press; New York; USA (1990).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert, Dieter C.
RA   Willems, Marjolaine
RA   Cassiman, Jean-Jacques
RA   Frizzell, Raymond A.
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   Patent=US5576206;
RA   Schlegel, Richard
RT   "Human papilloma virus genes and their use in gene therapy.";
RL   Patent number US5576206, 19-Nov-1996.
//
RX   PubMed=7684560; DOI=10.1152/ajpcell.1993.264.5.C1219;
RA   Yankaskas, James Robert
RA   Haizlip, Jill Elaine
RA   Conrad, Melissa
RA   Koval, Debra
RA   Lazarowski, Eduardo
RA   Paradiso, Anthony Mark
RA   Rinehart, Clifford Atley Jr.
RA   Sarkadi, Balazs
RA   Schlegel, Richard
RA   Boucher, Richard C.
RT   "Papilloma virus immortalized tracheal epithelial cells retain a
RT   well-differentiated phenotype.";
RL   Am. J. Physiol. 264:C1219-C1230(1993).
//