Cellosaurus cell line T560.2.F7 (CVCL

Cellosaurus T560.2.F7 (CVCL_F727)

Cross-references
Cell line name	T560.2.F7
Accession	CVCL_F727
Resource Identification Initiative	To cite this cell line use: T560.2.F7 (RRID:CVCL_F727)
Comments	Characteristics: Secretes polyreactive IgG2a antibodies whose known ligands include phosphorylcholine, 2,4,6,trinitrophenyl-determinant, human TNF-beta and polystyrene. Can switches spontaneously from IgG2a to IgA (PubMed=10433101; PubMed=11683378).
Disease	Mouse lymphoma (NCIt: C21602)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: B10 x B10.H-2aH-4b.
Hierarchy	Parent: CVCL_F726 (T560.2)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=1535783; DOI=10.1093/intimm/4.2.107 T. Dharma Rao, Azzam A. Maghazachi, Ana Maria Caetano Faria, Ross S. Basch, Julia M. Phillips-Quagliata; T560: an (H-2b x H-2a) F1 hybrid, phosphorylcholine (PC)-binding, murine B cell lymphoma that bears receptors for IgA and IgG, presents antigen and secretes IL-4. Int. Immunol. 4:107-118(1992) PubMed=10433101; DOI=10.3109/08916939908998536 Julia M. Phillips-Quagliata, Ana Maria Caetano Faria, Jing-Kang Han, Deborah H. Spencer, Geoffrey Haughton, Paolo Casali; The IgG2a/IgA produced by the murine T560 B lymphoma that arose during a graft-versus-host reaction is polyreactive and somatically mutated. Autoimmunity 29:215-233(1999) PubMed=11683378; DOI=10.3109/08916930109008046 Julia M. Phillips-Quagliata, Ana Maria Caetano Faria, Jing-Kang Han, Deborah H. Spencer, Geoffrey Haughton, Paolo Casali; IgG2a and IgA co-expression by the natural autoantibody-producing murine B lymphoma T560. Autoimmunity 33:181-197(2001)
Encyclopedic resources	Wikidata; Q54971591
Entry history
Entry creation	11-Feb-2013
Last entry update	14-Aug-2025
Version number	7