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Cellosaurus TY08 (CVCL_F712)

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Cell line name TY08
Accession CVCL_F712
Resource Identification Initiative To cite this cell line use: TY08 (RRID:CVCL_F712)
Comments Population: Japanese.
Characteristics: Exhibits a robust proliferation at the permissive temperature of 33 Celsius. Cell growth is arrested at 37 Celsius (PubMed=20458752).
Characteristics: These cells do not grow beyond the 16th to 18th passages, even under the permissive temperature (DOI=10.1111/cen3.12001).
Doubling time: ~3 days (PubMed=20458752).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Brain, microvascular endothelium; UBERON=UBERON_0000955+UBERON_0008339.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_U943 (TY09)CVCL_LH57 (TY10)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Conditionally immortalized cell line
Publications

PubMed=20458752; DOI=10.1002/jcp.22232
Yasuteru Sano, Fumitaka Shimizu, Masaaki Abe, Toshihiko Maeda, Yoko Kashiwamura, Sumio Ohtsuki, Tetsuya Terasaki, Masuo Obinata, Koji Kajiwara, Masami Fujii, Michiyasu Suzuki, Takashi Kanda;
Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function.
J. Cell. Physiol. 225:519-528(2010)

DOI=10.1111/cen3.12001
Yasuteru Sano, Yoko Kashiwamura, Masaaki Abe, Le-Ha Dieu, Jorg Huwyler, Fumitaka Shimizu, Hiroyo Haruki, Toshihiko Maeda, Kazuyuki Saito, Ayako Tasaki, Takashi Kanda;
Stable human brain microvascular endothelial cell line retaining its barrier-specific nature independent of the passage number.
Clin. Exp. Neuroimmunol. 4:92-103(2013)

Cross-references
Encyclopedic resources Wikidata; Q54973450
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number13