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Cellosaurus HepG2/Luc GPC3- (CVCL_F6LC)

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Cell line name HepG2/Luc GPC3-
Synonyms H2K7
Accession CVCL_F6LC
Resource Identification Initiative To cite this cell line use: HepG2/Luc GPC3- (RRID:CVCL_F6LC)
Comments Population: Caucasian.
Characteristics: Stably transduced with pLenti-C-Luciferase-P2A-Puro.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4451; GPC3.
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Miscellaneous: Cell line information from personal communication of Fayn, Stanley.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F0T3 (Hep-G2 GPC3 KO)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Entry history
Entry creation22-Oct-2026
Last entry update22-Oct-2026
Version number1