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Cellosaurus SNU449/GPC3-OE (CVCL_F6L8)

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Cell line name SNU449/GPC3-OE
Synonyms S4GA3
Accession CVCL_F6L8
Resource Identification Initiative To cite this cell line use: SNU449/GPC3-OE (RRID:CVCL_F6L8)
Comments Population: Korean.
Characteristics: Stably transduced with pLenti-GPC3-mGFP-P2A-Puro expressing human GPC3 (glypican-3) fused to mGFP.
Genetic integration: Method=Transduction; Gene=FPbase; GJETS; TagGFP2 (Note=Green fluorescent protein derived from Aequorea macrodactyla GFP).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:4451; GPC3.
Genetic integration: Method=Transduction; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Miscellaneous: Cell line information from personal communication of Fayn, Stanley.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Glu2250Argfs*28 (c.6747dupA); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Arg712Ter (c.2134C>T); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys139Arg (c.416A>G); ClinVar=VCV001500748; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ala161Thr (c.481G>A); ClinVar=VCV000161518; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0454 (SNU-449)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
Entry history
Entry creation22-Oct-2026
Last entry update22-Oct-2026
Version number1