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Cellosaurus EDITGENE TLR7 and TLR8 Knockout THP-1 Cell Line (CVCL_F6JI)

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Cell line name EDITGENE TLR7 and TLR8 Knockout THP-1 Cell Line
Synonyms TLR7 and TLR8 Knockout THP-1 Cell Line
Accession CVCL_F6JI
Resource Identification Initiative To cite this cell line use: EDITGENE TLR7 and TLR8 Knockout THP-1 Cell Line (RRID:CVCL_F6JI)
Comments Population: Japanese.
Characteristics: Growth mode Suspension.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:15631; TLR7.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:15632; TLR8.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): EDITGENE=EDC07593

Markers:
AmelogeninX,Y
CSF1PO11,13
D1S165616,17
D2S133817,18
D3S135815,17
D5S81811,12
D7S82010
D8S117910,14
D12S39119
D13S31713
D16S53911,12
D18S5113,14
D19S43312.2,13
D21S1130,31.2
FGA24,25
Penta D10,12
Penta E11,15
TH018,9.3
TPOX8,11
vWA16

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Cross-references
Cell line collections (Providers) EDITGENE; EDC07593
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1