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Cellosaurus EDITGENE CMTM6 Knockout A-375 Cell Line (CVCL_F6JE)

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Cell line name EDITGENE CMTM6 Knockout A-375 Cell Line
Synonyms CMTM6 Knockout A-375 Cell Line
Accession CVCL_F6JE
Resource Identification Initiative To cite this cell line use: EDITGENE CMTM6 Knockout A-375 Cell Line (RRID:CVCL_F6JE)
Comments Population: Caucasian.
Characteristics: Growth mode Adherent.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:19177; CMTM6.
Genetic integration: Method=CRISPR/Cas9; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): EDITGENE=EDC07544

Markers:
AmelogeninX
CSF1PO11,12
D2S44111
D2S133816,24
D3S135815,17
D5S81812
D6S104311,14
D7S8209
D8S117911,14
D12S39118,21
D13S31711,14
D16S5399
D18S5112,17
D19S43313,14.2
D21S1129,30
FGA23
Penta D9,15
Penta E10,12
TH018
TPOX8,10
vWA16,17

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Cross-references
Cell line collections (Providers) EDITGENE; EDC07544
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1