Cellosaurus cell line KS Y-1 (CVCL

Cellosaurus KS Y-1 (CVCL_F660)

Cross-references
Cell line name	KS Y-1
Synonyms	KS Y1; KSY-1
Accession	CVCL_F660
Resource Identification Initiative	To cite this cell line use: KS Y-1 (RRID:CVCL_F660)
Comments	Group: Patented cell line. Problematic cell line: Contaminated. Shown to be a T24 derivative (PubMed=22987579). Was thought to originate from the pleural effusion of a male AIDS patient with Kaposi sarcoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00408. Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11448. Population: Caucasian; Swedish. Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations	Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
Disease	Bladder carcinoma (NCIt: C4912)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0554 (T24)
Sex of cell	Female
Age at sampling	82Y
Category	Cancer cell line
Web pages	Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/ksy-1-atcc-crl-11448 Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	PubMed=7629884; DOI=10.1093/jnci/87.13.974 Yanto Lunardi-Iskandar, Parkash Singh Gill, Victor H. Lam, Robert A. Zeman, Frank Michaels, Dean L. Mann, Marvin S. Reitz Jr., Mark H. Kaplan, Zwi N. Berneman, Darryl Carter, Joseph L. Bryant, Robert Charles Gallo; Isolation and characterization of an immortal neoplastic cell line (KS Y-1) from AIDS-associated Kaposi's sarcoma. J. Natl. Cancer Inst. 87:974-981(1995) Patent=US5569602 Yanto Lunardi-Iskandar, Robert Charles Gallo; First immortalized Kaposi's sarcoma cell line. Patent number US5569602, 29-Oct-1996 DOI=10.1007/0-306-46861-1_10 Chris Boshoff; Kaposi's sarcoma. (In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.157-166; Kluwer Academic Publishers; New York; USA (1999) PubMed=22987579; DOI=10.1002/ijc.27849 Michael Sturzl, Dominika Gaus, Wilhelm Gerhard Dirks, Donald Emil Ganem, Ramona Jochmann; Kaposi's sarcoma-derived cell line SLK is not of endothelial origin, but is a contaminant from a known renal carcinoma cell line. Int. J. Cancer 132:1954-1958(2013)
Cell line databases/resources	cancercelllines; CVCL_F660
Biological sample resources	BioSample; SAMN03151948
Encyclopedic resources	Wikidata; Q54900488
Entry history
Entry creation	11-Feb-2013
Last entry update	10-Apr-2025
Version number	25