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Cellosaurus IST-1 [Human contaminated placenta] (CVCL_F642)

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Cell line name IST-1 [Human contaminated placenta]
Accession CVCL_F642
Resource Identification Initiative To cite this cell line use: IST-1 [Human contaminated placenta] (RRID:CVCL_F642)
Comments Problematic cell line: Contaminated. Shown to be a SK-OV-3 derivative. Originally thought to originate from an HPV16 immortalized first trimester placenta.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00402.
Population: Caucasian.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2734

Markers:
AmelogeninX
CSF1PO10,11,12
D5S81811,12
D7S8209,10,13,14
D13S3178,11,12
D16S53910,12,13
TH017,8,9,9.3
TPOX6,8,9,11
vWA16,17,18

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/ist-1-atcc-crl-2734
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9701564; DOI=10.1242/jcs.111.17.2655
Ie-Ming Shih, Tian-Li Wang, Tzyy-Choou Wu, Robert J. Kurman, John David Gearhart;
Expression of Mel-CAM in implantation site intermediate trophoblastic cell line, IST-1, limits its migration on uterine smooth muscle cells.
J. Cell Sci. 111:2655-2664(1998)

Cross-references
Cell line collections (Providers) ATCC; CRL-2734 - Discontinued
Cell line databases/resources cancercelllines; CVCL_F642
Biological sample resources BioSample; SAMN03151922
BioSample; SAMN03471780
Encyclopedic resources Wikidata; Q54898330
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number31