ID   IST-1 [Human contaminated placenta]
AC   CVCL_F642
DR   ATCC; CRL-2734
DR   BioSample; SAMN03151922
DR   BioSample; SAMN03471780
DR   cancercelllines; CVCL_F642
DR   Wikidata; Q54898330
RX   PubMed=9701564;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/ist-1-atcc-crl-2734
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a SK-OV-3 derivative. Originally thought to originate from an HPV16 immortalized first trimester placenta.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00402.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: ATCC; CRL-2734; true.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
ST   Source(s): ATCC=CRL-2734
ST   Amelogenin: X
ST   CSF1PO: 10,11,12
ST   D13S317: 8,11,12
ST   D16S539: 10,12,13
ST   D5S818: 11,12
ST   D7S820: 9,10,13,14
ST   TH01: 7,8,9,9.3
ST   TPOX: 6,8,9,11
ST   vWA: 16,17,18
DI   NCIt; C7978; Ovarian serous cystadenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0532 ! SK-OV-3
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 31
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RX   PubMed=9701564; DOI=10.1242/jcs.111.17.2655;
RA   Shih, Ie-Ming
RA   Wang, Tian-Li
RA   Wu, Tzyy-Choou
RA   Kurman, Robert J.
RA   Gearhart, John David
RT   "Expression of Mel-CAM in implantation site intermediate trophoblastic
RT   cell line, IST-1, limits its migration on uterine smooth muscle
RT   cells.";
RL   J. Cell Sci. 111:2655-2664(1998).
//