Cellosaurus cell line EDITGENE S1PR1 Knockout U251 MG Cell Line (CVCL

Cross-references
Cell line name	EDITGENE S1PR1 Knockout U251 MG Cell Line
Synonyms	S1PR1 Knockout U251 MG Cell Line
Accession	CVCL_F5C0
Resource Identification Initiative	To cite this cell line use: EDITGENE S1PR1 Knockout U251 MG Cell Line (RRID:CVCL_F5C0)
Comments	Population: Caucasian. Characteristics: Growth mode Adherent. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3165; S1PR1. Genetic integration: Method=CRISPR/Cas9; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
Sequence variations	Mutation; HGNC; HGNC:5382; IDH1; None_reported; -; Zygosity=- (from parent cell line). Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease	Astrocytoma (NCIt: C60781) Astrocytoma (ORDO: Orphanet_94)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0021 (U-251MG)
Sex of cell	Male
Age at sampling	75Y
Category	Cancer cell line
Cell line collections (Providers)	EDITGENE; EDC07681
Entry history
Entry creation	25-Jun-2026
Last entry update	25-Jun-2026
Version number	1