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Cellosaurus TC-106 (CVCL_F531)

[Text version]
Cell line name TC-106
Synonyms TC106
Accession CVCL_F531
Resource Identification Initiative To cite this cell line use: TC-106 (RRID:CVCL_F531)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Ewing Sarcoma Cell Line Atlas (ESCLA).
Part of: MD Anderson Cell Lines Project.
Omics: Genomics; ChIP-seq; ERG.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Scalp; UBERON=UBERON_0000403.
Sequence variations
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX
CSF1PO11,13
D2S133824,26
D3S135816,17
D5S81812,13
D7S8209,10
D8S117912,13
D13S31710,11
D16S53913
D18S5117,18
D19S43312
D21S1129,31.2
FGA21,22
TH019.3
TPOX8,10
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ESCLA; -; https://hgserver1.amc.nl/cgi-bin/r2/main.cgi?option=about_dscope
Info; MCLP; -; https://tcpaportal.org/mclp/
Provider; CCR; -; https://www.cccells.org/tables/Ewings.php
Publications

PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4
Jacqueline Whang-Peng, Timothy J. Triche, Turid Knutsen, James S. Miser, Chien-Song Kao-Shan, Schickwann Tsai, Mark A. Israel;
Cytogenetic characterization of selected small round cell tumors of childhood.
Cancer Genet. Cytogenet. 21:185-208(1986)

PubMed=3390826
Catherine McKeon, Carol Jeanne Thiele, Robert A. Ross, Michael Kwan, Timothy J. Triche, James S. Miser, Mark A. Israel;
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.
Cancer Res. 48:4307-4311(1988)

DOI=10.1016/B978-0-12-333530-2.50006-X
Mark A. Israel, Carol Jeanne Thiele;
Tumor cell lines of the peripheral nervous system.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.43-78; Academic Press; New York; USA (1994)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

DOI=10.5282/edoc.27750
Martin Franz Orth;
Systematic multi-omics profiling of Ewing sarcoma cell lines.
Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany

PubMed=36476851; DOI=10.1016/j.celrep.2022.111761; PMCID=PMC10333306
Martin Franz Orth, Didier Surdez, Tobias Faehling, Anna C. Ehlers, Aruna Marchetto, Sandrine Grossetete-Lalami, Richard Volckmann, Danny A. Zwijnenburg, Julia Sophie Gerke, Sakina Zaidi, Javier Alonso ...Show all 25 authors... , Ana Sastre, Sylvain Baulande, Martin Sill, Florencia Cidre-Aranaz, Shunya Ohmura, Thomas Kirchner, Stefanie M. Hauck, Eva Reischl, Melissa Gymrek, Stefan Michael Pfister, Konstantin Strauch, Jan Koster, Olivier Delattre, Thomas Georg Philipp Grunewald; Show fewer authors
Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation.
Cell Rep. 41:111761.1-111761.28(2022)

Cross-references
Cell line databases/resources cancercelllines; CVCL_F531
Cell_Model_Passport; SIDM01468
DepMap; ACH-001283
Encyclopedic resources Wikidata; Q54971788
Gene expression databases GEO; GSM5359706
GEO; GSM5359707
GEO; GSM5359708
GEO; GSM5359709
GEO; GSM5359710
GEO; GSM5359711
GEO; GSM5362910
GEO; GSM5362911
GEO; GSM5362918
GEO; GSM5362919
GEO; GSM5362920
GEO; GSM5362921
GEO; GSM5364021
GEO; GSM5364022
GEO; GSM5364023
GEO; GSM5364024
GEO; GSM5364025
Polymorphism and mutation databases Cosmic; 2228235
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number26