ID   TC-106
AC   CVCL_F531
SY   TC106
DR   cancercelllines; CVCL_F531
DR   Cell_Model_Passport; SIDM01468
DR   Cosmic; 2228235
DR   DepMap; ACH-001283
DR   GEO; GSM5359706
DR   GEO; GSM5359707
DR   GEO; GSM5359708
DR   GEO; GSM5359709
DR   GEO; GSM5359710
DR   GEO; GSM5359711
DR   GEO; GSM5362910
DR   GEO; GSM5362911
DR   GEO; GSM5362918
DR   GEO; GSM5362919
DR   GEO; GSM5362920
DR   GEO; GSM5362921
DR   GEO; GSM5364021
DR   GEO; GSM5364022
DR   GEO; GSM5364023
DR   GEO; GSM5364024
DR   GEO; GSM5364025
DR   Wikidata; Q54971788
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RX   DOI=10.5282/edoc.27750;
RX   PubMed=3004699;
RX   PubMed=3390826;
RX   PubMed=25010205;
RX   PubMed=28196595;
RX   PubMed=36476851;
WW   Info; ESCLA; -; https://hgserver1.amc.nl/cgi-bin/r2/main.cgi?option=about_dscope
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Provider; CCR; -; https://www.cccells.org/tables/Ewings.php
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Ewing Sarcoma Cell Line Atlas (ESCLA).
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=25010205).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG; Note=EWSR1 exon 7 with ERG exon 6 (PubMed=25010205; PubMed=36476851).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Lys3326Ter (c.9976A>T) (10204A>T); ClinVar=VCV000038266; Zygosity=Unspecified (PubMed=25010205).
CC   Omics: Genomics; ChIP-seq; ERG.
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K27me3.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Scalp; UBERON=UBERON_0000403.
ST   Source(s): PubMed=25010205
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 10,11
ST   D16S539: 13
ST   D18S51: 17,18
ST   D19S433: 12
ST   D21S11: 29,31.2
ST   D2S1338: 24,26
ST   D3S1358: 16,17
ST   D5S818: 12,13
ST   D7S820: 9,10
ST   D8S1179: 12,13
ST   FGA: 21,22
ST   TH01: 9.3
ST   TPOX: 8,10
ST   vWA: 16,18
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 26
//
RX   DOI=10.1016/B978-0-12-333530-2.50006-X;
RA   Israel M.A., Thiele C.J.;
RT   "Tumor cell lines of the peripheral nervous system.";
RL   (In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.43-78; Academic Press; New York; USA (1994).
//
RX   DOI=10.5282/edoc.27750;
RA   Orth M.F.;
RT   "Systematic multi-omics profiling of Ewing sarcoma cell lines.";
RL   Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
//
RX   PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4;
RA   Whang-Peng J., Triche T.J., Knutsen T., Miser J.S., Kao-Shan C.-S.,
RA   Tsai S., Israel M.A.;
RT   "Cytogenetic characterization of selected small round cell tumors of
RT   childhood.";
RL   Cancer Genet. Cytogenet. 21:185-208(1986).
//
RX   PubMed=3390826;
RA   McKeon C., Thiele C.J., Ross R.A., Kwan M., Triche T.J., Miser J.S.,
RA   Israel M.A.;
RT   "Indistinguishable patterns of protooncogene expression in two
RT   distinct but closely related tumors: Ewing's sarcoma and
RT   neuroepithelioma.";
RL   Cancer Res. 48:4307-4311(1988).
//
RX   PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782;
RA   Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S.,
RA   Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y.,
RA   Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H.,
RA   Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S.,
RA   Catchpoole D., Llombart-Bosch A., Waldman T.A., Khan J.;
RT   "The genomic landscape of the Ewing sarcoma family of tumors reveals
RT   recurrent STAG2 mutation.";
RL   PLoS Genet. 10:e1004475.1-e1004475.13(2014).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=36476851; DOI=10.1016/j.celrep.2022.111761; PMCID=PMC10333306;
RA   Orth M.F., Surdez D., Faehling T., Ehlers A.C., Marchetto A.,
RA   Grossetete-Lalami S., Volckmann R., Zwijnenburg D.A., Gerke J.S., Zaidi S.,
RA   Alonso J., Sastre A., Baulande S., Sill M., Cidre-Aranaz F., Ohmura S.,
RA   Kirchner T., Hauck S.M., Reischl E., Gymrek M., Pfister S.M., Strauch K.,
RA   Koster J., Delattre O., Grunewald T.G.P.;
RT   "Systematic multi-omics cell line profiling uncovers principles of
RT   Ewing sarcoma fusion oncogene-mediated gene regulation.";
RL   Cell Rep. 41:111761.1-111761.28(2022).
//