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Cellosaurus HyCyte MDA-MB-436 stable cell line for hBRCA1 overexpression (CVCL_F4VK)

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Cell line name HyCyte MDA-MB-436 stable cell line for hBRCA1 overexpression
Synonyms MDA-MB-436 stable cell line for hBRCA1 overexpression
Accession CVCL_F4VK
Resource Identification Initiative To cite this cell line use: HyCyte MDA-MB-436 stable cell line for hBRCA1 overexpression (RRID:CVCL_F4VK)
Comments Population: Caucasian.
Characteristics: Transduced with pLV[Exp]-CMV>hBRCA1[NM_007296.2](ns):T2A:Bsd.
Doubling time: 60-72 hours (Hysigen=CGSC-M25731).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1100; BRCA1.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:3701; FHIT; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; c.5277+1G>A; ClinVar=VCV000037654; Zygosity=Hemizygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly203fs*9 (c.607_608ins227); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204fs*7 (c.610_612delinsGCGTGTGG); Zygosity=Unspecified (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0623 (MDA-MB-436)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGSC-M25731
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1