ID   HyCyte MDA-MB-436 stable cell line for hBRCA1 overexpression
AC   CVCL_F4VK
SY   MDA-MB-436 stable cell line for hBRCA1 overexpression
DR   Hysigen; CGSC-M25731
CC   Population: Caucasian.
CC   Characteristics: Transduced with pLV[Exp]-CMV>hBRCA1[NM_007296.2](ns):T2A:Bsd.
CC   Doubling time: 60-72 hours (Hysigen=CGSC-M25731).
CC   Sequence variation: Gene deletion; HGNC; HGNC:3701; FHIT; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1100; BRCA1; Simple; c.5277+1G>A; ClinVar=VCV000037654; Zygosity=Hemizygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly203fs*9 (c.607_608ins227); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204fs*7 (c.610_612delinsGCGTGTGG); Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1100; BRCA1.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0623 ! MDA-MB-436
SX   Female
AG   43Y
CA   Cancer cell line
DT   Created: 25-06-26; Last updated: 25-06-26; Version: 1
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