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Cellosaurus HyCyte NB4 stable cell line for hBCL6B overexpression (CVCL_F4SQ)

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Cell line name HyCyte NB4 stable cell line for hBCL6B overexpression
Synonyms NB4 stable cell line for hBCL6B overexpression
Accession CVCL_F4SQ
Resource Identification Initiative To cite this cell line use: HyCyte NB4 stable cell line for hBCL6B overexpression (RRID:CVCL_F4SQ)
Comments Population: Caucasian.
Characteristics: Transduced with pLV[Exp]-CMV>hBCL6B[NM_181844.4]-EF1A>copGFP:T2A:Puro-WPRE.
Doubling time: 18-24 hours (Hysigen=CGSC-M33831).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; EGFP.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1002; BCL6B.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:9113; PML + HGNC; HGNC:9864; RARA; Name(s)=PML-RARA (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Acute promyelocytic leukemia with PML-RARA (NCIt: C3182)
Acute promyelocytic leukemia (ORDO: Orphanet_520)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0005 (NB4)
Sex of cell Female
Age at sampling 23Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGSC-M33831
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1