Cellosaurus cell line HyCyte OVCAR-8 KO-hSMARCA4 (CVCL

Cross-references
Cell line name	HyCyte OVCAR-8 KO-hSMARCA4
Synonyms	hSMARCA4 knockout OVCAR-8 cell line
Accession	CVCL_F4J4
Resource Identification Initiative	To cite this cell line use: HyCyte OVCAR-8 KO-hSMARCA4 (RRID:CVCL_F4J4)
Comments	Population: Caucasian. Doubling time: 24-36 hours (Hysigen=CGKO-M3490). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11100; SMARCA4.
Sequence variations	Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Disease	High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1629 (OVCAR-8)
Sex of cell	Female
Age at sampling	64Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M3490
Entry history
Entry creation	25-Jun-2026
Last entry update	25-Jun-2026
Version number	1