Cellosaurus cell line HyCyte DU145 KO-hGCDH (CVCL

Cross-references
Cell line name	HyCyte DU145 KO-hGCDH
Synonyms	hGCDH knockout DU145 cell line
Accession	CVCL_F4DQ
Resource Identification Initiative	To cite this cell line use: HyCyte DU145 KO-hGCDH (RRID:CVCL_F4DQ)
Comments	Population: Caucasian. Doubling time: 36-48 hours (Hysigen=CGKO-M3288). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4189; GCDH. Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
Sequence variations	Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp84Tyr (c.250G>T) (p.Arg98Leu, c.293G>T); ClinVar=VCV000376306; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:9884; RB1; Simple; p.Lys715Ter (c.2143A>T); ClinVar=VCV001786615; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11389; STK11; Simple; p.Lys178fs*86 (c.532_536delAAGCC); Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro223Leu (c.668C>T); ClinVar=VCV000234214; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val274Phe (c.820G>T); ClinVar=VCV000376674; Zygosity=Heterozygous (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0105 (DU145)
Sex of cell	Male
Age at sampling	69Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M3288
Entry history
Entry creation	25-Jun-2026
Last entry update	25-Jun-2026
Version number	1